Enzyme publications

Driving new research

Scientific research is key to our product offerings. We have over 20 years of experience in performing clinical trials and post-marketing studies, engaging in international, multidisciplinary collaborations across the globe to help build knowledge around our product concepts. Explore publications that support enzymes below.

Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease
Dariusz Stepniak, Liesbeth Spaenij-Dekking, Cristina Mitea, Martine Moester, Arnoud de Ru, Renee Baak-Pablo, Peter van Veelen, Luppo Edens, Frits Koning
Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4): G621-9

Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease
C Mitea, R Havenaar, J Wouter Drijfhout, L Edens, L Dekking, F Koning
Gut, 2008 Jan;57(1): 25-32

Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers
B N Salden, V Monserrat, F J Troost, M J Bruins, L Edens, R Bartholomé, G R Haenen, B Winkens, F Koning, A A Masclee
Aliment Pharmacol Ther. 2015 Aug;42(3): 273-85

Influence of dietary components on Aspergillus niger prolyl endoprotease mediated gluten degradation
Veronica Montserrat, Maaike J Bruins, Luppo Edens, Frits Koning
Food Chem, 2015 May 1: 174:440-5

Ineffective degradation of immunogenic gluten epitopes by currently available digestive enzyme supplements
George Janssen, Chantal Christis, Yvonne Kooy-Winkelaar, Luppo Edens, Drew Smith, Peter van Veelen, Frits Koning
PLoS One, 2015 Jun 1;10(6): e0128065

Randomized clinical trial: Effective gluten degradation by Aspergillus niger-derived enzyme in a complex meal setting
Julia König, Savanne Holster, Maaike J Bruins, Robert J Brummer
Sci Rep. 2017 Oct 12;7(1): 13100

Beneficial effects of oral tilactase on patients with hypolactasia
P Portincasa, A Di Ciaula, M Vacca, R Montelli, D Q-H Wang, G Palasciano
Eur J Clin Invest. 2008 Nov;38(11): 835-44

The effect of oral supplementation with Lactobacillus reuteri or tilactase in lactose intolerant patients: randomized trial
V Ojetti, G Gigante, M Gabrielli, M E Ainora, A Mannocci, E C Lauritano, G Gasbarrini, A Gasbarrini
Eur Rev Med Pharmacol Sci. 2010 Mar;14(3): 163-70

Enzyme replacement for lactose malabsorption using a beta-D-galactosidase
J A DiPalma, M S Collins
J Clin Gastroenterol, 1989 Jun;11(3): 290-3

Effective reduction of lactose maldigestion in preschool children by direct addition of beta-galactosidases to milk at mealtime
C Barillas, N W Solomons
Pediatrics, 1987 May;79(5): 766-72

Efficacy of lactase-treated milk for lactose-intolerant pediatric patients
J A Biller, S King, A Rosenthal, R J Grand
J Pediatr. 1987 Jul;111(1): 91-4

Related articles
  • Probiotics for IBS—what’s next? Explore the potential of synbiotics and microencapsulated butyrate with leading gut health scientist

    Probiotics for IBS—what’s next? Explore the potential of synbiotics and microencapsulated butyrate with leading gut health scientist

    New clinical research reveals that a combination of synbiotics and microencapsulated butyrate can improve IBS symptoms in just four weeks.

  • The gut microbiome as a pathway to supporting children with autism: New study reveals synbiotics' dual benefits for digestive and behavioral symptoms

    The gut microbiome as a pathway to supporting children with autism: New study reveals synbiotics' dual benefits for digestive and behavioral symptoms

    Discover new clinical evidence highlighting the potential of synbiotic supplementation in autism spectrum disorder (ASD).

  • Unlock mineral bioavailability: How phytase breaks through absorption barriers

    Unlock mineral bioavailability: How phytase breaks through absorption barriers

    Discover how dsm-firmenich's Tolerase® P phytase enhances mineral bioavailability by breaking down phytic acid in plant-based foods.

How can we help you?

  • New partnership request

    Have an idea for a new project, a groundbreaking innovation, or a need for expert services? Let’s talk.

  • Sample request

    Don’t just take our word for it. Discover how our solutions can support your product development journey. 

  • Quote request

    Tell us about your project needs. We’ll build you a tailored quote.